Role of MMP-2 (-1306 C/T) Polymorphism in Pituitary Adenoma
نویسندگان
چکیده
منابع مشابه
Role of MMP-2 (-1306 C/T) Polymorphism in Pituitary Adenoma
Purpose. To determine if the frequency of the genotype of MMP-2 (-1306 C/T) Rs243865 has an influence on the development of pituitary adenoma (PA). Methods. The study enrolled n = 84 patients with PA and a random sample of the population n = 318 (reference group). The genotyping test of MMP-2 (-1306 C/T) was carried out using the real-time polymerase chain reaction method. Results. Analysis of ...
متن کاملDoes MMP-9 Gene Polymorphism Play a Role in Pituitary Adenoma Development?
Purpose. To determine if the MMP-9 genotype has an influence on development of pituitary adenoma (PA). Methodology. The study enrolled n = 86 patients with PA and n = 526 healthy controls (reference group). The genotyping of MMP-9 was carried out using the real-time polymerase chain reaction method. Results. Our data demonstrated that the MMP-9 (-1562) C/C genotype was more frequent in PA group...
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Background The pathogenesis of pituitary adenoma (PA) is complex and poorly understood. It is thought that PA has a multifactorial aetiology; genetic factors also have an impact on PA development. Since MMP1 and FGFR4 genes play an important role in tumour growth, differentiation and progression, we decided to determine if the frequency of the genotypes of MMP-1 and FGFR4-R388 polymorphisms inf...
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Matrix metalloproteinases (MMPs) are a large family of zinc-containing proteases several functions of the MMPs were identified in various systems such as cell migration/invasion, apopto-sis/cell survival, and angiogenesis (1). Besides, MMP-2 and MMP-9 have important implications in the progression and invasiveness of several hematological malignancies, including Hodgkin lymphomas (HL), malignan...
متن کاملMR imaging of pituitary adenoma: CT, clinical, and surgical correlation.
Twenty-five patients with suspected pituitary adenoma were evaluated prospectively with CT and MR. Nine patients underwent transsphenoidal surgery, and three of these showed a documented decrease in size of mass on bromocriptine therapy. CT was more sensitive than MR for detecting focal lesions (seven vs three) and sellar-floor erosion (12 vs six). MR was superior to CT in identifying infundibu...
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ژورنال
عنوان ژورنال: Scientifica
سال: 2016
ISSN: 2090-908X
DOI: 10.1155/2016/2839697